Cheap flights from Southern Minnesota

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Southern Minnesota Flight Information
Origin airport IATA code
MSP

Sourcing the best flights from Southern Minnesota on ebookers

If you’re seeking a flight from Southern Minnesota, you can swiftly and easily find exactly what you’re looking for using ebookers. Our easy-to-use tool will let you select the destination and ideal travel dates to immediately see which routes and airlines are available. Have a preferred airline in mind for the trip? You can filter your ebookers search to see if they have flights from MSP. For more bespoke options, you can also set your search for multiple destinations and flights that are refundable, so you can have the most relevant information in moments.

Getting the best deal on a cheap flight from MSP

There are a few golden rules for keeping costs low when booking flights from Southern Minnesota. The first thing to think about is being flexible on your travel dates. It can help to shift your departure by a day, or even a few hours, as prices can vary by significant amounts. Use ebookers to compare and contrast your options ahead of time, and you can make a savvy decision. Want more savings? If book the hotel at your chosen destination through ebookers while also arranging your flight from Southern Minnesota, you can get a discount of up to 15% off the total price. For help on which pad to pick, you can make use of our snappy hotel descriptions, which are accompanied by useful photos.

Getting things going at your destination

With ebookers, you don’t just have access to the latest, constantly updated information on flights from MSP. You can also get inspiration on the most interesting things to get up to when you’re there. Just check out our Things to Do tool and you’ll soon be drawing up an exciting itinerary. And if you’re keen to take in as much of the wider area as possible, you could also look into the best car hire deals and have your very own set of wheels waiting, so you can roam to your heart’s content.

Featured Hotels near Southern Minnesota

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
The price is €120 per night from 4 Apr to 5 Apr
€120
4 Apr - 5 Apr
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at EVEN Hotel Rochester - Mayo Clinic Area by IHG. During your stay, you're just a quick walk from Mayo Clinic Hospital - Saint Marys Campus. Enjoy features like free WiFi in public areas, plus an indoor pool and a restaurant. This property offers pet-friendly amenities, such as food and water bowls.
9.4/10 Exceptional! (1,000 reviews)
Very clean. Ɓed was way too soft. The dining menu was limited but good. Had 3 meals there and were very satisfied. Servers were all incredible.

Reviewed on 25 Mar 2026

Opens in a new windowEVEN Hotel Rochester - Mayo Clinic Area by IHG
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
The price is €146 per night from 1 Apr to 2 Apr
€146
1 Apr - 2 Apr
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Aspen Suites. During your stay, you're just a quick walk from Mayo Clinic Hospital - Saint Marys Campus. Features include free breakfast, free WiFi in public areas and free self-parking.
9/10 Wonderful! (777 reviews)
The staff is incredibly friendly and accommodating. A free shuttle to Mayo Clinic stops right outside the front lobby doors, Mayo St. Mary's Hospital is just across the street, and there are several restaurant options in walking distance from the property. The kitchenette in the suite, complementary ...

Reviewed on 26 Mar 2026

Opens in a new windowAspen Suites
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
The price is €103 per night from 3 Apr to 4 Apr
€103
3 Apr - 4 Apr
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Hotel Indigo Rochester – Mayo Clinic Area by IHG. During your stay, you'll be connected to the convention centre and just a quick walk from Shops University Square. Features include free WiFi in public areas, plus a restaurant and a gym.
8.8/10 Excellent! (968 reviews)
Our room was not very big for a queen size bed. The second floor lobby with no street-level direct access was inconvenient. The hotel shares a lobby with Crave restaurant so there really isn’t a hotel lobby dedicated for guests. The skyway access to Mayo Clinic is very nice and convenient.

Reviewed on 26 Mar 2026

Opens in a new windowHotel Indigo Rochester – Mayo Clinic Area by IHG
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Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
The price is €134 per night from 29 Mar to 30 Mar
€134
29 Mar - 30 Mar
includes taxes & fees
Kahler Grand Hotel's great location gets high marks from our customers. During your stay, you'll be connected to the convention centre and just a quick walk from Shops University Square. Enjoy features like free WiFi in public areas, plus 2 restaurants and an indoor pool.
8.4/10 Very Good! (1,964 reviews)
No breakfast Parking in structure attached to hotel

Reviewed on 27 Mar 2026

Opens in a new windowKahler Grand Hotel
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
The price is €94 per night from 31 Mar to 1 Apr
€94
31 Mar - 1 Apr
includes taxes & fees
Our customers tell us that they can't get enough of the free breakfast at Best Western Rochester Hotel Mayo Clinic Area/St. Mary's. During your stay, you'll be within walking distance of Apache Mall. Free WiFi in public areas, free self-parking and an indoor pool are available.
8.4/10 Very Good! (864 reviews)
This was your second time staying here. Our first time we were in a pool side room and it was fine. Our second time thr tub wouldn’t drain. I went to the front desk. The front desk employee was so rude about it. The hot tub wasn’t “hot” and they do not enforce the 15 people in the hot tub rule even ...

Reviewed on 27 Mar 2026

Opens in a new windowBest Western Rochester Hotel Mayo Clinic Area/St. Mary's
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
The price is €139 per night from 28 Mar to 29 Mar
€139
28 Mar - 29 Mar
includes taxes & fees
Kahler Inn and Suites - Mayo Clinic Area's great location gets high marks from our customers. During your stay, you're just a quick walk from American Cancer Society Hope Lodge. Enjoy features like free breakfast and free WiFi in public areas, plus an indoor pool.
8/10 Very Good! (1,541 reviews)
Breakfast was great. Staff awesome. Room clean. Parking challenging

Reviewed on 27 Mar 2026

Opens in a new windowKahler Inn and Suites - Mayo Clinic Area
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Fare, taxes & fees: Fares were found on ebookers.com and are updated daily. They include all taxes and fees, except baggage fees.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a £25.00 / 45.00 Euro service fee charged by ebookers, plus any airline fare and tax increase that may be applicable.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.